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Document type:
journal article 
Author(s):
Willuweit, A; Velden, J; Godemann, R; Manook, A; Jetzek, F; Tintrup, H; Kauselmann, G; Zevnik, B; Henriksen, G; Drzezga, A; Pohlner, J; Schoor, M; Kemp, JA; von der Kammer, H 
Title:
Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease. 
Abstract:
BACKGROUND: Transgenic mice expressing mutated amyloid precursor protein (APP) and presenilin (PS)-1 or -2 have been successfully used to model cerebral beta-amyloidosis, one of the characteristic hallmarks of Alzheimer's disease (AD) pathology. However, the use of many transgenic lines is limited by premature death, low breeding efficiencies and late onset and high inter-animal variability of the pathology, creating a need for improved animal models. Here we describe the detailed characterizati...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2009 
Journal volume:
Journal issue:
11 
Pages contribution:
e7931 
Language:
eng 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik