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Dokumenttyp:
journal article 
Autor(en):
Kneilling, M; Mailhammer, R; Hültner, L; Schönberger, T; Fuchs, K; Schaller, M; Bukala, D; Massberg, S; Sander, CA; Braumüller, H; Eichner, M; Maier, KL; Hallmann, R; Pichler, BJ; Haubner, R; Gawaz, M; Pfeffer, K; Biedermann, T; Röcken, M 
Titel:
Direct crosstalk between mast cell-TNF and TNFR1-expressing endothelia mediates local tissue inflammation. 
Abstract:
Signaling through tumor necrosis factor receptor 1 (TNFR1) controls bacterial infections and the induction of inflammatory Th1 cell-mediated autoimmune diseases. By dissecting Th1 cell-mediated delayed-type hypersensitivity responses (DTHRs) into single steps, we localized a central defect to the missing TNFR1 expression by endothelial cells (ECs). Adoptive transfer and mast cell knockin experiments into Kit(W)/Kit(W-v), TNF(-/-), and TNFR1(-/-) mice showed that the signaling defect exclusively...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2009 
Band / Volume:
114 
Heft / Issue:
Seitenangaben Beitrag:
1696-706 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik