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Document type:
journal article 
Author(s):
Renström, J; Istvanffy, R; Gauthier, K; Shimono, A; Mages, J; Jardon-Alvarez, A; Kröger, M; Schiemann, M; Busch, DH; Esposito, I; Lang, R; Peschel, C; Oostendorp, RA 
Title:
Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells. 
Abstract:
Secreted frizzled-related protein 1 (Sfrp1) is highly expressed by stromal cells maintaining hematopoietic stem cells (HSCs). Sfrp1 loss in stromal cells increases production of hematopoietic progenitors, and in knockout mice, dysregulates hemostasis and increases Flk2- Cd34- Lin- Sca1+ Kit+ (LSK) cell numbers in bone marrow. Also, LSK and multipotent progenitors (MPPs) resided mainly in the G0/G1 phase of cell cycle, with an accompanying decrease in intracellular beta-catenin levels. Gene-expre...    »
 
Journal title abbreviation:
Cell Stem Cell 
Year:
2009 
Journal volume:
Journal issue:
Pages contribution:
157-67 
Language:
eng 
Print-ISSN:
1934-5909 
TUM Institution:
III. Medizinische Klinik und Poliklinik; r Medizinische Mikrobiologie, Immunologie und Hygiene; r Allgemeine Pathologie und pathologische Anatomie