Lung cancer is one of the most common malignancies worldwide. EGF receptor-mediated signaling pathways play an important role in tumorgenicity. The membrane-
bound metalloproteinase TACE induces EGFR activation through the proteolytic cleavage and maturation of EGFR ligand pro-forms. In this work the role of TACE for proliferation and transformation of non-small cell lung cancer cells was investigated. For the majority of the experiments, TACE expression was permanently downregulated by using small hairpin RNA technology. We could demonstrate, that TACE plays a critical role in proliferation as well as in transformation. This could only partly be explained by the activation of the EGF Receptor. The finding might have implications for future treatment options of the non-small cell lung cancer.
«
Lung cancer is one of the most common malignancies worldwide. EGF receptor-mediated signaling pathways play an important role in tumorgenicity. The membrane-
bound metalloproteinase TACE induces EGFR activation through the proteolytic cleavage and maturation of EGFR ligand pro-forms. In this work the role of TACE for proliferation and transformation of non-small cell lung cancer cells was investigated. For the majority of the experiments, TACE expression was permanently downregulated by...
»