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Dokumenttyp:
journal article 
Autor(en):
El-Gogo, S; Flach, B; Staib, C; Sutter, G; Adler, H 
Titel:
In vivo attenuation of recombinant murine gammaherpesvirus 68 (MHV-68) is due to the expression and immunogenicity but not to the insertion of foreign sequences. 
Abstract:
Recombinant herpesviruses are increasingly utilized to study herpesvirus biology. For recombinant viruses carrying insertions of foreign sequences, attenuated phenotypes in vivo have been frequently observed. In most cases, the underlying mechanisms were not clear or have not been investigated. In this study, we used a recombinant murine gammaherpesvirus 68 (MHV-68), carrying a cassette for the expression of the non-structural protein NS3 of Hepatitis C virus (MHV-68-NS3), to systematically addr...    »
 
Zeitschriftentitel:
Virology 
Jahr:
2008 
Band / Volume:
380 
Heft / Issue:
Seitenangaben Beitrag:
322-7 
Sprache:
eng 
Print-ISSN:
0042-6822 
TUM Einrichtung:
r Virologie