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Dokumenttyp:
journal article 
Autor(en):
Grundler, R; Brault, L; Gasser, C; Bullock, AN; Dechow, T; Woetzel, S; Pogacic, V; Villa, A; Ehret, S; Berridge, G; Spoo, A; Dierks, C; Biondi, A; Knapp, S; Duyster, J; Schwaller, J 
Titel:
Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. 
Abstract:
FLT3-ITD-mediated leukemogenesis is associated with increased expression of oncogenic PIM serine/threonine kinases. To dissect their role in FLT3-ITD-mediated transformation, we performed bone marrow reconstitution assays. Unexpectedly, FLT3-ITD cells deficient for PIM1 failed to reconstitute lethally irradiated recipients, whereas lack of PIM2 induction did not interfere with FLT3-ITD-induced disease. PIM1-deficient bone marrow showed defects in homing and migration and displayed decreased surf...    »
 
Zeitschriftentitel:
J Exp Med 
Jahr:
2009 
Band / Volume:
206 
Heft / Issue:
Seitenangaben Beitrag:
1957-70 
Sprache:
eng 
Print-ISSN:
0022-1007 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik