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Dokumenttyp:
journal article 
Autor(en):
Sharma, S; Kumar, S; Sud, N; Wiseman, DA; Tian, J; Rehmani, I; Datar, S; Oishi, P; Fratz, S; Venema, RC; Fineman, JR; Black, SM 
Titel:
Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow. 
Abstract:
Previous studies demonstrate impaired nitric oxide (NO) signaling in children and animal models with congenital heart defects and increased pulmonary blood flow. However, the molecular mechanisms underlying these alterations remain incompletely understood. The purpose of this study was to determine if early changes in arginine metabolic pathways could play a role in the reduced NO signaling demonstrated in our lamb model of congenital heart disease with increased pulmonary blood flow (Shunt lamb...    »
 
Zeitschriftentitel:
Vascul Pharmacol 
Jahr:
2009 
Band / Volume:
51 
Heft / Issue:
5-6 
Seitenangaben Beitrag:
359-64 
Sprache:
eng 
Print-ISSN:
1537-1891 
TUM Einrichtung:
r Kinderkardiologie und angeborene Herzfehler