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Dokumenttyp:
journal article 
Autor(en):
Bennett, JL; Lam, C; Kalluri, SR; Saikali, P; Bautista, K; Dupree, C; Glogowska, M; Case, D; Antel, JP; Owens, GP; Gilden, D; Nessler, S; Stadelmann, C; Hemmer, B 
Titel:
Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. 
Abstract:
OBJECTIVE: The serum of most neuromyelitis optica (NMO) patients contains autoantibodies (NMO-IgGs) directed against the aquaporin-4 (AQP4) water channel located on astrocyte foot processes in the perivessel and subpial areas of the brain. Our objectives were to determine the source of central nervous system (CNS) NMO-IgGs and their role in disease pathogenesis. METHODS: Fluorescence-activated cell sorting and single-cell reverse transcriptase polymerase chain reaction were used to identify over...    »
 
Zeitschriftentitel:
Ann Neurol 
Jahr:
2009 
Band / Volume:
66 
Heft / Issue:
Seitenangaben Beitrag:
617-29 
Sprache:
eng 
Print-ISSN:
0364-5134 
TUM Einrichtung:
Neurologische Klinik und Poliklinik