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Dokumenttyp:
journal article 
Autor(en):
Drecoll, E; Gaertner, FC; Miederer, M; Blechert, B; Vallon, M; Müller, JM; Alke, A; Seidl, C; Bruchertseifer, F; Morgenstern, A; Senekowitsch-Schmidtke, R; Essler, M 
Titel:
Treatment of peritoneal carcinomatosis by targeted delivery of the radio-labeled tumor homing peptide bi-DTPA-[F3]2 into the nucleus of tumor cells. 
Abstract:
BACKGROUND: Alpha-particle emitting isotopes are effective novel tools in cancer therapy, but targeted delivery into tumors is a prerequisite of their application to avoid toxic side effects. Peritoneal carcinomatosis is a widespread dissemination of tumors throughout the peritoneal cavity. As peritoneal carcinomatosis is fatal in most cases, novel therapies are needed. F3 is a tumor homing peptide which is internalized into the nucleus of tumor cells upon binding to nucleolin on the cell surfac...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2009 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e5715 
Sprache:
eng 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie