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Dokumenttyp:
journal article 
Autor(en):
Di Lullo, G; Soprana, E; Panigada, M; Palini, A; Erfle, V; Staib, C; Sutter, G; Siccardi, AG 
Titel:
Marker gene swapping facilitates recombinant Modified Vaccinia Virus Ankara production by host-range selection. 
Abstract:
Modified Vaccinia Virus Ankara (MVA) is employed widely as an experimental and human vaccine vector for its lack of replication in mammalian cells and high expression of heterologous genes. Recombinant MVA technology can be improved greatly by combining transient host-range selection (based on the restoration in MVA of the deleted vaccinia gene K1L) with the differential expression of fluorescent proteins. Recombinant virus results from swapping a red protein gene (in the acceptor virus) with a...    »
 
Zeitschriftentitel:
J Virol Methods 
Jahr:
2009 
Band / Volume:
156 
Heft / Issue:
1-2 
Seitenangaben Beitrag:
37-43 
Sprache:
eng 
Print-ISSN:
0166-0934 
TUM Einrichtung:
r Virologie