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Document type:
journal article 
Author(s):
Di Bonito, P; Grasso, F; Mochi, S; Petrone, L; Fanales-Belasio, E; Mei, A; Cesolini, A; Laconi, G; Conrad, H; Bernhard, H; Dembek, CJ; Cosma, A; Santini, SM; Lapenta, C; Donati, S; Muratori, C; Giorgi, C; Federico, M 
Title:
Anti-tumor CD8+ T cell immunity elicited by HIV-1-based virus-like particles incorporating HPV-16 E7 protein. 
Abstract:
Here we report a novel strategy for the induction of CD8(+) T cell adaptive immune response against viral and tumor antigens. This approach relies on high levels of incorporation in HIV-1 VLPs of a mutant of HIV-1 Nef (Nef(mut)) which can act as anchoring element for foreign proteins. By in vitro assay, we found that VLP-associated Nef(mut) is efficiently cross-presented by antigen presenting cells. Inoculation in mice of VLPs incorporating the HPV-16 E7 protein fused to Nef(mut) led to an anti-...    »
 
Journal title abbreviation:
Virology 
Year:
2009 
Journal volume:
395 
Journal issue:
Pages contribution:
45-55 
Language:
eng 
Print-ISSN:
0042-6822 
TUM Institution:
III. Medizinische Klinik und Poliklinik; r Virologie