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Document type:
journal article 
Author(s):
Herroeder, S; Reichardt, P; Sassmann, A; Zimmermann, B; Jaeneke, D; Hoeckner, J; Hollmann, MW; Fischer, KD; Vogt, S; Grosse, R; Hogg, N; Gunzer, M; Offermanns, S; Wettschureck, N 
Title:
Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility. 
Abstract:
Integrin-mediated adhesion plays a central role in T cell trafficking and activation. Genetic inactivation of the guanine nucleotide-binding (G) protein alpha-subunits Galpha(12) and Galpha(13) resulted in an increased activity of integrin leukocyte-function-antigen-1 in murine CD4(+) T cells. The interaction with allogeneic dendritic cells was enhanced, leading to an abnormal proliferative response in vitro. In vivo, T cell-specific inactivation of Galpha(12) and Galpha(13) caused lymphadenopat...    »
 
Journal title abbreviation:
Immunity 
Year:
2009 
Journal volume:
30 
Journal issue:
Pages contribution:
708-20 
Language:
eng 
Print-ISSN:
1074-7613 
TUM Institution:
die