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Document type:
journal article 
Author(s):
Zini, E; Osto, M; Franchini, M; Guscetti, F; Donath, MY; Perren, A; Heller, RS; Linscheid, P; Bouwman, M; Ackermann, M; Lutz, TA; Reusch, CE 
Title:
Hyperglycaemia but not hyperlipidaemia causes beta cell dysfunction and beta cell loss in the domestic cat. 
Abstract:
AIMS/HYPOTHESIS: In vitro studies point to a toxic effect of high glucose and non-esterified fatty acids on beta cells. Whether elevated levels of glucose and lipids induce beta cell loss in vivo is less clear. The domestic cat has recently been proposed as a valuable animal model for human type 2 diabetes because feline diabetes shows several similarities with diabetes in humans, including obesity-induced insulin resistance, impaired beta cell function, decreased number of beta cells and pancre...    »
 
Journal title abbreviation:
Diabetologia 
Year:
2009 
Journal volume:
52 
Journal issue:
Pages contribution:
336-46 
Language:
eng 
Print-ISSN:
0012-186X 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie