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Dokumenttyp:
journal article 
Autor(en):
Vollmar, P; Nessler, S; Kalluri, SR; Hartung, HP; Hemmer, B 
Titel:
The antidepressant venlafaxine ameliorates murine experimental autoimmune encephalomyelitis by suppression of pro-inflammatory cytokines. 
Abstract:
Antidepressants are known to impact on the immune system. In this study, we examined the immunomodulatory properties of venlafaxine, a selective serotonin/norepinephrine reuptake inhibitor (SNRI), in murine experimental autoimmune encephalomyelitis (EAE), a T-cell-mediated CNS demyelinating disease model of multiple sclerosis. EAE was induced in SJL/J mice by adoptive transfer of myelin-specific T cells. Mice received different doses of venlafaxine before induction and after onset of disease. Su...    »
 
Zeitschriftentitel:
Int J Neuropsychopharmacol 
Jahr:
2009 
Band / Volume:
12 
Heft / Issue:
Seitenangaben Beitrag:
525-36 
Sprache:
eng 
Print-ISSN:
1461-1457 
TUM Einrichtung:
Neurologische Klinik und Poliklinik