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Document type:
journal article 
Author(s):
Martin, Mdel P; Cravens, PD; Winger, R; Kieseier, BC; Cepok, S; Eagar, TN; Zamvil, SS; Weber, MS; Frohman, EM; Kleinschmidt-Demasters, BK; Montine, TJ; Hemmer, B; Marra, CM; Stüve, O 
Title:
Depletion of B lymphocytes from cerebral perivascular spaces by rituximab. 
Abstract:
BACKGROUND: Rituximab is a recombinant chimeric monoclonal antibody against CD20, a molecule expressed on cells of the B-cell lineage. A phase 2 clinical trial recently provided strong evidence of the beneficial effects of rituximab in patients with relapsing-remitting multiple sclerosis. We and other investigators previously demonstrated that rituximab therapy depletes B lymphocytes from peripheral blood and cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis. OBJECTIVE:...    »
 
Journal title abbreviation:
Arch Neurol 
Year:
2009 
Journal volume:
66 
Journal issue:
Pages contribution:
1016-20 
Language:
eng 
Print-ISSN:
0003-9942 
TUM Institution:
Neurologische Klinik und Poliklinik