Accelerated aging of the putamen in men but not in women.

Nunnemann, S; Wohlschläger, AM; Ilg, R; Gaser, C; Etgen, T; Conrad, B; Zimmer, C; Muhlau, M

doi:10.1016/j.neurobiolaging.2007.05.016

journal article

Dokumenttyp:: Journal Article; Research Support, Non-U.S. Gov't
Autor(en):: Nunnemann, S; Wohlschläger, AM; Ilg, R; Gaser, C; Etgen, T; Conrad, B; Zimmer, C; Muhlau, M
Titel:: Accelerated aging of the putamen in men but not in women.
Abstract:: Age-related structural brain changes have been demonstrated repeatedly but data on the effect of gender on age-related structural brain changes are conflicting. Using high-resolution T1-weighted magnetic resonance imaging and voxel-based morphometry, we examined a population of 133 healthy adults (women, 73; men, 60; age range, 29-80 years) focusing on differential aging between men and women (i.e., interaction of age and gender). Compared to women, men showed accelerated age-related gray matter (GM) loss in the posterior putamen. Our data may constitute the structural substrate for age-related differences in motor function between men and women such as the higher incidence and earlier onset of Parkinson's disease in men. «
Age-related structural brain changes have been demonstrated repeatedly but data on the effect of gender on age-related structural brain changes are conflicting. Using high-resolution T1-weighted magnetic resonance imaging and voxel-based morphometry, we examined a population of 133 healthy adults (women, 73; men, 60; age range, 29-80 years) focusing on differential aging between men and women (i.e., interaction of age and gender). Compared to women, men showed accelerated age-related gray matt... »
Zeitschriftentitel:: Neurobiol Aging
Jahr:: 2009
Band / Volume:: 30
Heft / Issue:: 1
Seitenangaben Beitrag:: 147-51
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.neurobiolaging.2007.05.016
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/17611000
Print-ISSN:: 0197-4580
TUM Einrichtung:: Fachgebiet Neuroradiologie (Prof. Zimmer); Klinik und Poliklinik für Psychiatrie und Psychotherapie; Neurologische Klinik und Poliklinik
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