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Dokumenttyp:
journal article 
Autor(en):
Steinberg, C; Eisenächer, K; Gross, O; Reindl, W; Schmitz, F; Ruland, J; Krug, A 
Titel:
The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection. 
Abstract:
IFN regulatory factor 7 (IRF7) has been described as the master regulator of type I IFN responses and has been shown to be critical for innate antiviral immunity in vivo. In addition to type I IFN, NK cell responses are involved in the control of viral replication during acute viral infection. To investigate the role of IRF7 in the context of a viral infection that induces a strong NK cell response, the murine cytomegalovirus (MCMV) infection model was used. WT, IRF7-deficient and IRF3/IRF7-doub...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2009 
Band / Volume:
39 
Heft / Issue:
Seitenangaben Beitrag:
1007-18 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik; III. Medizinische Klinik und Poliklinik; r Medizinische Mikrobiologie, Immunologie und Hygiene