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Dokumenttyp:
journal article 
Autor(en):
Schlenk, RF; Döhner, K; Kneba, M; Götze, K; Hartmann, F; Del Valle, F; Kirchen, H; Koller, E; Fischer, JT; Bullinger, L; Habdank, M; Späth, D; Groner, S; Krebs, B; Kayser, S; Corbacioglu, A; Anhalt, A; Benner, A; Fröhling, S; Döhner, H; German-Austrian AML Study Group (AMLSG) 
Titel:
Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B. 
Abstract:
BACKGROUND: In a previous randomized trial, AML HD98B, we showed that administration of all-trans retinoic acid in addition to intensive chemotherapy improved the outcome of older patients with acute myeloid leukemia. The objectives of this study were to evaluate the prognostic impact of gene mutations and to identify predictive genetic factors for the all-trans retinoic acid treatment effect. DESIGN AND METHODS: Data from mutation analyses of the NPM1, CEBPA, FLT3, and MLL genes were correlated...    »
 
Zeitschriftentitel:
Haematologica 
Jahr:
2009 
Band / Volume:
94 
Heft / Issue:
Seitenangaben Beitrag:
54-60 
Sprache:
eng 
Print-ISSN:
0390-6078 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik