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- Document type:
- Clinical Trial; Journal Article
- Author(s):
- Warm, M; Kates, R; Dick, M; Thomas, A; Mallmann, P; Hoopmann, M; Harbeck, N
- Title:
- Optimized pro-active management of anemia by Epoetin alpha in pre-operative chemotherapy for primary breast cancer.
- Abstract:
- This prospective study quantifies the response of hemoglobin and other blood factors to Epoetin alpha (EPO) administration in the course of pre-operative chemotherapy in breast cancer. Blood count time series were analyzed in 38 primary breast cancer patients with/without EPO during the course of pre-operative chemotherapy with epirubicin and paclitaxel. EPO injections improved blood counts in 'anemic' patients (< or =12.0 g/dl) receiving chemotherapy, but had little effect when administered to patients with higher hemoglobin concentrations. On the average, without chemotherapy, hemoglobin concentrations drifted toward about 11.1 g/dl without EPO but could be maintained at near 12.0 g/dl with EPO. In conclusion, there is potential for improved anemia management using EPO during pre-operative chemotherapy, which not only benefits quality of life but could also influence long-term survival in breast cancer through improved tumor oxygenation.
- Journal title abbreviation:
- Oncol Rep
- Year:
- 2009
- Journal volume:
- 21
- Journal issue:
- 3
- Pages contribution:
- 777-85
- Language:
- eng
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/19212639
- Print-ISSN:
- 1021-335X
- TUM Institution:
- Frauenklinik und Poliklinik
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