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Document type:
journal article 
Author(s):
Descot, A; Hoffmann, R; Shaposhnikov, D; Reschke, M; Ullrich, A; Posern, G 
Title:
Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction. 
Abstract:
We analyzed the G-actin-regulated transcriptome by gene expression analysis using previously characterized actin-binding drugs. We found many known MAL/MRTF-dependent target genes of serum response factor (SRF), as well as additional directly regulated genes. Surprisingly, several putative antiproliferative target genes were identified, including mig6/errfi-1, a negative regulator of the EGFR family. Mig6 induction occurred through actin-MAL-SRF signaling, and MAL was inducibly recruited to and...    »
 
Journal title abbreviation:
Mol Cell 
Year:
2009 
Journal volume:
35 
Journal issue:
Pages contribution:
291-304 
Language:
eng 
Print-ISSN:
1097-2765 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene