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Document type:
journal article 
Author(s):
Kohlhof, H; Hampel, F; Hoffmann, R; Burtscher, H; Weidle, UH; Hölzel, M; Eick, D; Zimber-Strobl, U; Strobl, LJ 
Title:
Notch1, Notch2, and Epstein-Barr virus-encoded nuclear antigen 2 signaling differentially affects proliferation and survival of Epstein-Barr virus-infected B cells. 
Abstract:
The canonical mode of transcriptional activation by both the Epstein-Barr viral protein, Epstein-Barr virus-encoded nuclear antigen 2 (EBNA2), and an activated Notch receptor (Notch-IC) requires their recruitment to RBPJ, suggesting that EBNA2 uses the Notch pathway to achieve B-cell immortalization. To gain further insight into the biologic equivalence between Notch-IC and EBNA2, we performed a genome-wide expression analysis, revealing that Notch-IC and EBNA2 exhibit profound differences in th...    »
 
Journal title abbreviation:
Blood 
Year:
2009 
Journal volume:
113 
Journal issue:
22 
Pages contribution:
5506-15 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene