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Document type:
journal article 
Author(s):
Roozendaal, R; Mempel, TR; Pitcher, LA; Gonzalez, SF; Verschoor, A; Mebius, RE; von Andrian, UH; Carroll, MC 
Title:
Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. 
Abstract:
To track drainage of lymph-borne small and large antigens (Ags) into the peripheral lymph nodes and subsequent encounter by B cells and follicular dendritic cells, we used the approach of multiphoton intravital microscopy. We find a system of conduits that extend into the follicles and mediate delivery of small antigens to cognate B cells and follicular dendritic cells. The follicular conduits provide an efficient and rapid mechanism for delivery of small antigens and chemokines such as CXCL13 t...    »
 
Journal title abbreviation:
Immunity 
Year:
2009 
Journal volume:
30 
Journal issue:
Pages contribution:
264-76 
Language:
eng 
Print-ISSN:
1074-7613 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene