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Document type:
journal article 
Author(s):
Ben Fredj, R; Gross, E; Ben Ahmed, S; Hassine, H; Saguem, S 
Title:
The dihydrouracil/uracil ratio in plasma, clinical and genetic analysis for screening of dihydropyrimidine dehydrogenase deficiency in colorectal cancer patients treated with 5-fluorouracil. 
Abstract:
A rapid and cost-effective reversed phase high performance liquid chromatography (HPLC) method for quantification of dihydrouracil to uracil ratio (UH2/U) in plasma has been developed and used to screen for dihydropyrimidine dehydrogenase (DPD) deficiency in nine patients treated with 5-fluorouracil (5-FU). This HPLC method is based on the use of a simultaneous UV detection at 205 and 268nm during the analysis run of the plasma extract and taking into account the particularity that UH2 shows no...    »
 
Journal title abbreviation:
Pathol Biol (Paris) 
Year:
2009 
Journal volume:
57 
Journal issue:
Pages contribution:
470-6 
Language:
eng 
Print-ISSN:
0369-8114 
TUM Institution:
Frauenklinik und Poliklinik