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Document type:
Journal Article; Article 
Author(s):
Ceyhan, GO; Deucker, S; Demir, IE; Erkan, M; Schmelz, M; Bergmann, F; Müller, MW; Giese, T; Büchler, MW; Giese, NA; Friess, H 
Title:
Neural fractalkine expression is closely linked to pain and pancreatic neuritis in human chronic pancreatitis. 
Abstract:
The chemokine fractalkine induces migration of inflammatory cells into inflamed tissues, thereby aggravating inflammatory tissue damage and fibrosis. Furthermore, fractalkine increases neuropathic pain through glial activation, which can be diminished by blocking of its receptor, CX3CR1, through neutralizing antibodies. As chronic pancreatitis (CP) is characterized by tissue infiltration of inflammatory cells, fibrosis, pancreatic neuritis and severe pain, the roles of fractalkine and CX3CR1 wer...    »
 
Journal title abbreviation:
Lab Invest 
Year:
2009 
Journal volume:
89 
Journal issue:
Pages contribution:
347-61 
Language:
eng 
Print-ISSN:
0023-6837 
TUM Institution:
Chirurgische Klinik und Poliklinik