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Document type:
journal article 
Author(s):
Weber, MS; Zamvil, SS 
Title:
Statins and demyelination. 
Abstract:
Statins are inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase, which are widely prescribed for their cholesterol-lowering properties in order to reduce atherogenesis and cardiovascular morbidity. Moreover, statins have been shown to exert pleiotropic immunomodulatory effects that might be of therapeutic benefit in autoimmune disorders. Statins appear to alter immune function largely independent of lipid lowering and rather through inhibition of posttranslational protein prenylati...    »
 
Journal title abbreviation:
Curr Top Microbiol Immunol 
Year:
2008 
Journal volume:
318 
Pages contribution:
313-24 
Language:
eng 
Print-ISSN:
0070-217X 
TUM Institution:
Neurologische Klinik und Poliklinik