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Dokumenttyp:
journal article 
Autor(en):
Bassermann, F; Frescas, D; Guardavaccaro, D; Busino, L; Peschiaroli, A; Pagano, M 
Titel:
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. 
Abstract:
In response to DNA damage in G2, mammalian cells must avoid entry into mitosis and instead initiate DNA repair. Here, we show that, in response to genotoxic stress in G2, the phosphatase Cdc14B translocates from the nucleolus to the nucleoplasm and induces the activation of the ubiquitin ligase APC/C(Cdh1), with the consequent degradation of Plk1, a prominent mitotic kinase. This process induces the stabilization of Claspin, an activator of the DNA-damage checkpoint, and Wee1, an inhibitor of ce...    »
 
Zeitschriftentitel:
Cell 
Jahr:
2008 
Band / Volume:
134 
Heft / Issue:
Seitenangaben Beitrag:
256-67 
Sprache:
eng 
Print-ISSN:
0092-8674 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik