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Document type:
journal article 
Author(s):
Bassermann, F; Frescas, D; Guardavaccaro, D; Busino, L; Peschiaroli, A; Pagano, M 
Title:
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. 
Abstract:
In response to DNA damage in G2, mammalian cells must avoid entry into mitosis and instead initiate DNA repair. Here, we show that, in response to genotoxic stress in G2, the phosphatase Cdc14B translocates from the nucleolus to the nucleoplasm and induces the activation of the ubiquitin ligase APC/C(Cdh1), with the consequent degradation of Plk1, a prominent mitotic kinase. This process induces the stabilization of Claspin, an activator of the DNA-damage checkpoint, and Wee1, an inhibitor of ce...    »
 
Journal title abbreviation:
Cell 
Year:
2008 
Journal volume:
134 
Journal issue:
Pages contribution:
256-67 
Language:
eng 
Print-ISSN:
0092-8674 
TUM Institution:
III. Medizinische Klinik und Poliklinik