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Document type:
journal article 
Author(s):
Köttgen, M; Buchholz, B; Garcia-Gonzalez, MA; Kotsis, F; Fu, X; Doerken, M; Boehlke, C; Steffl, D; Tauber, R; Wegierski, T; Nitschke, R; Suzuki, M; Kramer-Zucker, A; Germino, GG; Watnick, T; Prenen, J; Nilius, B; Kuehn, EW; Walz, G 
Title:
TRPP2 and TRPV4 form a polymodal sensory channel complex. 
Abstract:
The primary cilium has evolved as a multifunctional cellular compartment that decorates most vertebrate cells. Cilia sense mechanical stimuli in various organs, but the molecular mechanisms that convert the deflection of cilia into intracellular calcium transients have remained elusive. Polycystin-2 (TRPP2), an ion channel mutated in polycystic kidney disease, is required for cilia-mediated calcium transients but lacks mechanosensitive properties. We find here that TRPP2 utilizes TRPV4 to form a...    »
 
Journal title abbreviation:
J Cell Biol 
Year:
2008 
Journal volume:
182 
Journal issue:
Pages contribution:
437-47 
Language:
eng 
Print-ISSN:
0021-9525 
TUM Institution:
Urologische Klinik und Poliklinik