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Dokumenttyp:
journal article 
Autor(en):
Köttgen, M; Buchholz, B; Garcia-Gonzalez, MA; Kotsis, F; Fu, X; Doerken, M; Boehlke, C; Steffl, D; Tauber, R; Wegierski, T; Nitschke, R; Suzuki, M; Kramer-Zucker, A; Germino, GG; Watnick, T; Prenen, J; Nilius, B; Kuehn, EW; Walz, G 
Titel:
TRPP2 and TRPV4 form a polymodal sensory channel complex. 
Abstract:
The primary cilium has evolved as a multifunctional cellular compartment that decorates most vertebrate cells. Cilia sense mechanical stimuli in various organs, but the molecular mechanisms that convert the deflection of cilia into intracellular calcium transients have remained elusive. Polycystin-2 (TRPP2), an ion channel mutated in polycystic kidney disease, is required for cilia-mediated calcium transients but lacks mechanosensitive properties. We find here that TRPP2 utilizes TRPV4 to form a...    »
 
Zeitschriftentitel:
J Cell Biol 
Jahr:
2008 
Band / Volume:
182 
Heft / Issue:
Seitenangaben Beitrag:
437-47 
Sprache:
eng 
Print-ISSN:
0021-9525 
TUM Einrichtung:
Urologische Klinik und Poliklinik