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Document type:
journal article 
Author(s):
Kusmartsev, S; Eruslanov, E; Kübler, H; Tseng, T; Sakai, Y; Su, Z; Kaliberov, S; Heiser, A; Rosser, C; Dahm, P; Siemann, D; Vieweg, J 
Title:
Oxidative stress regulates expression of VEGFR1 in myeloid cells: link to tumor-induced immune suppression in renal cell carcinoma. 
Abstract:
Metastatic renal cell carcinoma (RCC) associates with overproduction of vascular endothelial growth factor (VEGF) due to the mutation/inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene. Herein we demonstrate that implantation of human RCC tumor cells into athymic nude mice promotes the appearance of VEGF receptor 1 (VEGFR1)/CD11b double-positive myeloid cells in peripheral blood. Avastin-mediated VEGF neutralization was capable of significantly reducing the numbers of circulating...    »
 
Journal title abbreviation:
J Immunol 
Year:
2008 
Journal volume:
181 
Journal issue:
Pages contribution:
346-53 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Urologische Klinik und Poliklinik