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Document type:
journal article 
Author(s):
Kusmartsev, S; Su, Z; Heiser, A; Dannull, J; Eruslanov, E; Kübler, H; Yancey, D; Dahm, P; Vieweg, J 
Title:
Reversal of myeloid cell-mediated immunosuppression in patients with metastatic renal cell carcinoma. 
Abstract:
PURPOSE: Tumor-induced immunosuppression remains a significant obstacle that limits the efficacy of biological therapy for renal cell carcinoma. Here we evaluate the role of CD33 myeloid-derived suppressor cells (MDSC) in the regulation of T-cell responses in renal cell carcinoma patients. We also examine effect of all-trans-retinoic acid (ATRA) on MDSC-mediated immune suppression. EXPERIMENTAL DESIGN: CD33-positive myeloid cells were isolated from the peripheral blood of renal cell carcinoma pa...    »
 
Journal title abbreviation:
Clin Cancer Res 
Year:
2008 
Journal volume:
14 
Journal issue:
24 
Pages contribution:
8270-8 
Language:
eng 
Print-ISSN:
1078-0432 
TUM Institution:
Urologische Klinik und Poliklinik