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Document type:
journal article 
Author(s):
Müller, I; Vaegler, M; Holzwarth, C; Tzaribatchev, N; Pfister, SM; Schütt, B; Reize, P; Greil, J; Handgretinger, R; Rudert, M 
Title:
Secretion of angiogenic proteins by human multipotent mesenchymal stromal cells and their clinical potential in the treatment of avascular osteonecrosis. 
Abstract:
Osteonecrosis is a frequent complication after treatment for childhood leukemia and other steroid-based therapies. The success rate of core decompression surgery is limited. Therefore, we evaluated relevant biological characteristics of human multipotent mesenchymal stromal cells (MSCs) in vitro. MSCs cultured under low-oxygen tensions showed decreased proliferation and differentiation into bone. However, these MSCs secreted significant amounts of vascular endothelial-derived factor in the prese...    »
 
Journal title abbreviation:
Leukemia 
Year:
2008 
Journal volume:
22 
Journal issue:
11 
Pages contribution:
2054-61 
Language:
eng 
Print-ISSN:
0887-6924 
TUM Institution:
dische Klinik und Poliklinik