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Document type:
journal article 
Author(s):
Helming, L; Tomasello, E; Kyriakides, TR; Martinez, FO; Takai, T; Gordon, S; Vivier, E 
Title:
Essential role of DAP12 signaling in macrophage programming into a fusion-competent state. 
Abstract:
Multinucleated giant cells, formed by fusion of macrophages, are a hallmark of granulomatous inflammation. With a genetic approach, we show that signaling through the adaptor protein DAP12 (DNAX activating protein of 12 kD), its associated receptor triggering receptor expressed by myeloid cells 2 (TREM-2), and the downstream protein tyrosine kinase Syk is required for the cytokine-induced formation of giant cells and that overexpression of DAP12 potentiates macrophage fusion. We also present evi...    »
 
Journal title abbreviation:
Sci Signal 
Year:
2008 
Journal volume:
Journal issue:
43 
Pages contribution:
ra11 
Language:
eng 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene