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Document type:
journal article 
Author(s):
Ying, S; Pettengill, M; Latham, ER; Walch, A; Ojcius, DM; Häcker, G 
Title:
Premature apoptosis of Chlamydia-infected cells disrupts chlamydial development. 
Abstract:
The obligate intracellular development of Chlamydia suggests that the bacteria should be vulnerable to premature host cell apoptosis, but because Chlamydia-infected cells are apoptosis resistant, this has never been able to be tested. We have devised a system to circumvent the apoptotic block imposed by chlamydial infection. When the proapoptotic protein Bim(S) was experimentally induced, epithelial cells underwent apoptosis that was not blocked by chlamydial infection. Apoptosis during the deve...    »
 
Journal title abbreviation:
J Infect Dis 
Year:
2008 
Journal volume:
198 
Journal issue:
10 
Pages contribution:
1536-44 
Language:
eng 
Print-ISSN:
0022-1899 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene