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Document type:
journal article 
Author(s):
Paschen, SA; Christian, JG; Vier, J; Schmidt, F; Walch, A; Ojcius, DM; Häcker, G 
Title:
Cytopathicity of Chlamydia is largely reproduced by expression of a single chlamydial protease. 
Abstract:
Chlamydiae replicate in a vacuole within epithelial cells and commonly induce cell damage and a deleterious inflammatory response of unknown molecular pathogenesis. The chlamydial protease-like activity factor (CPAF) translocates from the vacuole to the cytosol, where it cleaves several cellular proteins. CPAF is synthesized as an inactive precursor that is processed and activated during infection. Here, we show that CPAF can be activated in uninfected cells by experimentally induced oligomeriza...    »
 
Journal title abbreviation:
J Cell Biol 
Year:
2008 
Journal volume:
182 
Journal issue:
Pages contribution:
117-27 
Language:
eng 
Print-ISSN:
0021-9525 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene