Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Wagner, H 
Titel:
The sweetness of the DNA backbone drives Toll-like receptor 9. 
Abstract:
The prevailing paradigm ascribes activation of Toll-like receptor 9 (TLR9) to the detection of CpG-motifs within pathogen derived DNA. However, new work ties natural phospho-diester (PD) DNA recognition by TLR9 to the detection of the DNA sugar backbone 2' deoxyribose. PD 2' deoxyribose homopolymers lacking DNA bases (abasic) are shown to act as TLR9 agonist while abasic phospho-thioate (PS) 2' deoxyribose functions as TLR9 antagonist. Alignment of bases to PD 2' deoxyribose enhanced its TLR9 ag...    »
 
Zeitschriftentitel:
Curr Opin Immunol 
Jahr:
2008 
Band / Volume:
20 
Heft / Issue:
Seitenangaben Beitrag:
396-400 
Sprache:
eng 
Print-ISSN:
0952-7915 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene