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Document type:
journal article 
Author(s):
Heit, A; Gebhardt, F; Lahl, K; Neuenhahn, M; Schmitz, F; Anderl, F; Wagner, H; Sparwasser, T; Busch, DH; Kastenmüller, K 
Title:
Circumvention of regulatory CD4(+) T cell activity during cross-priming strongly enhances T cell-mediated immunity. 
Abstract:
Immunization with purified antigens is a safe and practical vaccination strategy but is generally unable to induce sustained CD8(+) T cell-mediated protection against intracellular pathogens. Most efforts to improve the CD8(+) T cell immunogenicity of these vaccines have focused on co-administration of adjuvant to support cross-presentation and dendritic cell maturation. In addition, it has been shown that CD4(+) T cell help during the priming phase contributes to the generation of protective CD...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2008 
Journal volume:
38 
Journal issue:
Pages contribution:
1585-97 
Language:
eng 
Print-ISSN:
0014-2980 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene