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Document type:
journal article 
Author(s):
Schlosser, E; Mueller, M; Fischer, S; Basta, S; Busch, DH; Gander, B; Groettrup, M 
Title:
TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses. 
Abstract:
Dendritic cells phagocytose pathogens leading to maturation and cross-presentation on MHC class I. We found that the efficiency of cross-priming in mice after vaccination with biodegradable poly(D,L-lactide-co-glycolide) microspheres (MSs) was enhanced when ovalbumin was coencapsulated together with either a CpG oligonucleotide or polyI:C as compared to co-inoculation of ovalbumin-bearing MS with soluble or separately encapsulated adjuvants. A single immunization with MS containing coencaspsulat...    »
 
Journal title abbreviation:
Vaccine 
Year:
2008 
Journal volume:
26 
Journal issue:
13 
Pages contribution:
1626-37 
Language:
eng 
Print-ISSN:
0264-410X 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene