User: Guest  Login
Document type:
journal article 
Author(s):
Farhat, K; Riekenberg, S; Heine, H; Debarry, J; Lang, R; Mages, J; Buwitt-Beckmann, U; Röschmann, K; Jung, G; Wiesmüller, KH; Ulmer, AJ 
Title:
Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling. 
Abstract:
TLR are primary triggers of the innate immune system by recognizing various microorganisms through conserved pathogen-associated molecular patterns. TLR2 is the receptor for a functional recognition of bacterial lipopeptides (LP) and is up-regulated during various disorders such as chronic obstructive pulmonary disease and sepsis. This receptor is unique in its ability to form heteromers with TLR1 or TLR6 to mediate intracellular signaling. According to the fatty acid pattern as well as the asse...    »
 
Journal title abbreviation:
J Leukoc Biol 
Year:
2008 
Journal volume:
83 
Journal issue:
Pages contribution:
692-701 
Language:
eng 
Print-ISSN:
0741-5400 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene