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Dokumenttyp:
journal article 
Autor(en):
Farhat, K; Riekenberg, S; Heine, H; Debarry, J; Lang, R; Mages, J; Buwitt-Beckmann, U; Röschmann, K; Jung, G; Wiesmüller, KH; Ulmer, AJ 
Titel:
Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling. 
Abstract:
TLR are primary triggers of the innate immune system by recognizing various microorganisms through conserved pathogen-associated molecular patterns. TLR2 is the receptor for a functional recognition of bacterial lipopeptides (LP) and is up-regulated during various disorders such as chronic obstructive pulmonary disease and sepsis. This receptor is unique in its ability to form heteromers with TLR1 or TLR6 to mediate intracellular signaling. According to the fatty acid pattern as well as the asse...    »
 
Zeitschriftentitel:
J Leukoc Biol 
Jahr:
2008 
Band / Volume:
83 
Heft / Issue:
Seitenangaben Beitrag:
692-701 
Sprache:
eng 
Print-ISSN:
0741-5400 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene