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Dokumenttyp:
journal article 
Autor(en):
Cirl, C; Wieser, A; Yadav, M; Duerr, S; Schubert, S; Fischer, H; Stappert, D; Wantia, N; Rodriguez, N; Wagner, H; Svanborg, C; Miethke, T 
Titel:
Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins. 
Abstract:
Pathogenic microbes have evolved sophisticated molecular strategies to subvert host defenses. Here we show that virulent bacteria interfere directly with Toll-like receptor (TLR) function by secreting inhibitory homologs of the Toll/interleukin-1 receptor (TIR) domain. Genes encoding TIR domain containing-proteins (Tcps) were identified in Escherichia coli CFT073 (TcpC) and Brucella melitensis (TcpB). We found that TcpC is common in the most virulent uropathogenic E. coli strains and promotes ba...    »
 
Zeitschriftentitel:
Nat Med 
Jahr:
2008 
Band / Volume:
14 
Heft / Issue:
Seitenangaben Beitrag:
399-406 
Sprache:
eng 
Print-ISSN:
1078-8956 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene