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Document type:
journal article 
Author(s):
Gratz, N; Siller, M; Schaljo, B; Pirzada, ZA; Gattermeier, I; Vojtek, I; Kirschning, CJ; Wagner, H; Akira, S; Charpentier, E; Kovarik, P 
Title:
Group A streptococcus activates type I interferon production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9. 
Abstract:
Bacterial pathogens are recognized by the innate immune system through pattern recognition receptors, such as Toll-like receptors (TLRs). Engagement of TLRs triggers signaling cascades that launch innate immune responses. Activation of MAPKs and NF-kappaB, elements of the major signaling pathways induced by TLRs, depends in most cases on the adaptor molecule MyD88. In addition, Gram-negative or intracellular bacteria elicit MyD88-independent signaling that results in production of type I interfe...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2008 
Journal volume:
283 
Journal issue:
29 
Pages contribution:
19879-87 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene