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Document type:
journal article 
Author(s):
Hofer, TP; Frankenberger, M; Mages, J; Lang, R; Meyer, P; Hoffmann, R; Colige, A; Ziegler-Heitbrock, L 
Title:
Tissue-specific induction of ADAMTS2 in monocytes and macrophages by glucocorticoids. 
Abstract:
The regulated expression of ADAMTS2 (a disintegrin and metalloproteinase with thrombospondin motifs), a secreted metalloproteinase involved in the processing of procollagen to collagen, was studied in peripheral blood mononuclear cells (PBMC). Stimulation with glucocorticoids (GC) resulted in a pronounced dose- and time-dependent increase of ADAMTS2 mRNA levels in PBMC. The increase of ADAMTS2 expression was specific for CD14++ monocytes (440-fold) and alveolar macrophages (200-fold), whereas CD...    »
 
Journal title abbreviation:
J Mol Med 
Year:
2008 
Journal volume:
86 
Journal issue:
Pages contribution:
323-32 
Language:
eng 
Print-ISSN:
0946-2716 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene