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Document type:
journal article 
Author(s):
Hölscher, C; Reiling, N; Schaible, UE; Hölscher, A; Bathmann, C; Korbel, D; Lenz, I; Sonntag, T; Kröger, S; Akira, S; Mossmann, H; Kirschning, CJ; Wagner, H; Freudenberg, M; Ehlers, S 
Title:
Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9. 
Abstract:
The role of Toll-like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (Mtb) infection remains controversial. To address the impact of TLR-mediated pathogen recognition and MyD88-dependent signaling events on anti-mycobacterial host responses, we analyzed the outcome of Mtb infection in TLR2/4/9 triple- and MyD88-deficient mice. After aerosol infection, both TLR2/4/9-deficient and wild-type mice expressed pro-inflammatory cytokines promoting antigen-specific T cells a...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2008 
Journal volume:
38 
Journal issue:
Pages contribution:
680-94 
Language:
eng 
Print-ISSN:
0014-2980 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene