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Dokumenttyp:
journal article 
Autor(en):
Klein, M; Obermaier, B; Angele, B; Pfister, HW; Wagner, H; Koedel, U; Kirschning, CJ 
Titel:
Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4. 
Abstract:
BACKGROUND: Recent studies have suggested that, in addition to Toll-like receptor (TLR) 2, other pattern recognition receptors mediate activation of the immune response after infection of the central nervous system (CNS) with Streptococcus pneumoniae (SP). METHODS: Using a mouse meningitis model, we investigated the influence of TLR4 single deficiency (TLR4(-/-)), TLR2/TLR4 double deficiency (TLR2/4(-/-)), and TLR2/TLR4/TLR9 triple deficiency (TLR2/4/9(-/-)) on the immune response of the CNS to...    »
 
Zeitschriftentitel:
J Infect Dis 
Jahr:
2008 
Band / Volume:
198 
Heft / Issue:
Seitenangaben Beitrag:
1028-36 
Sprache:
eng 
Print-ISSN:
0022-1899 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene