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Dokumenttyp:
journal article 
Autor(en):
Schmidt, R; Bültmann, A; Fischel, S; Gillitzer, A; Cullen, P; Walch, A; Jost, P; Ungerer, M; Tolley, ND; Lindemann, S; Gawaz, M; Schömig, A; May, AE 
Titel:
Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments nuclear factor kappaB-dependent inflammation in monocytes. 
Abstract:
In atherosclerosis, circulating platelets interact with endothelial cells and monocytes, leading to cell activation and enhanced recruitment of leukocytes into the vascular wall. The invasion of monocytes is accompanied by overexpression of matrix metalloproteinases (MMPs), which are thought to promote atherosclerosis and trigger plaque rupture. Following interaction with itself, the extracellular matrix metalloproteinase inducer (EMMPRIN) induces MMP synthesis via a little-known intracellular p...    »
 
Zeitschriftentitel:
Circ Res 
Jahr:
2008 
Band / Volume:
102 
Heft / Issue:
Seitenangaben Beitrag:
302-9 
Sprache:
eng 
Print-ISSN:
0009-7330 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik; III. Medizinische Klinik und Poliklinik