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Document type:
journal article 
Author(s):
Schmidt, R; Bültmann, A; Fischel, S; Gillitzer, A; Cullen, P; Walch, A; Jost, P; Ungerer, M; Tolley, ND; Lindemann, S; Gawaz, M; Schömig, A; May, AE 
Title:
Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments nuclear factor kappaB-dependent inflammation in monocytes. 
Abstract:
In atherosclerosis, circulating platelets interact with endothelial cells and monocytes, leading to cell activation and enhanced recruitment of leukocytes into the vascular wall. The invasion of monocytes is accompanied by overexpression of matrix metalloproteinases (MMPs), which are thought to promote atherosclerosis and trigger plaque rupture. Following interaction with itself, the extracellular matrix metalloproteinase inducer (EMMPRIN) induces MMP synthesis via a little-known intracellular p...    »
 
Journal title abbreviation:
Circ Res 
Year:
2008 
Journal volume:
102 
Journal issue:
Pages contribution:
302-9 
Language:
eng 
Print-ISSN:
0009-7330 
TUM Institution:
I. Medizinische Klinik und Poliklinik; III. Medizinische Klinik und Poliklinik