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Document type:
journal article 
Author(s):
Heger, U; Weitz, J; Lordick, F 
Title:
[Indications for pre- and postoperative treatment with imatinib for gastrointestinal stromal tumors] 
Abstract:
Imatinib is a tyrosine kinase inhibitor directed against the KIT and the PDGF-alpha receptors. Imatinib has proven efficacy in the treatment of metastatic GIST with a response rate achieving 70%, but treatment with imatinib alone is not curative. The median progression-free survival is about 2 years. In locally advanced GIST, primary treatment with imatinib proved to be safe and feasible in several cohort studies. The goal of any curatively intended surgical treatment for GIST is R0 resection. T...    »
 
Journal title abbreviation:
Chirurg 
Year:
2008 
Journal volume:
79 
Journal issue:
Pages contribution:
630-7 
Language:
de 
Print-ISSN:
0009-4722 
TUM Institution:
III. Medizinische Klinik und Poliklinik