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Document type:
journal article 
Author(s):
Jones, RB; Ndhlovu, LC; Barbour, JD; Sheth, PM; Jha, AR; Long, BR; Wong, JC; Satkunarajah, M; Schweneker, M; Chapman, JM; Gyenes, G; Vali, B; Hyrcza, MD; Yue, FY; Kovacs, C; Sassi, A; Loutfy, M; Halpenny, R; Persad, D; Spotts, G; Hecht, FM; Chun, TW; McCune, JM; Kaul, R; Rini, JM; Nixon, DF; Ostrowski, MA 
Title:
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. 
Abstract:
Progressive loss of T cell functionality is a hallmark of chronic infection with human immunodeficiency virus 1 (HIV-1). We have identified a novel population of dysfunctional T cells marked by surface expression of the glycoprotein Tim-3. The frequency of this population was increased in HIV-1-infected individuals to a mean of 49.4 +/- SD 12.9% of CD8(+) T cells expressing Tim-3 in HIV-1-infected chronic progressors versus 28.5 +/- 6.8% in HIV-1-uninfected individuals. Levels of Tim-3 expressio...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2008 
Journal volume:
205 
Journal issue:
12 
Pages contribution:
2763-79 
Language:
eng 
Print-ISSN:
0022-1007 
TUM Institution:
III. Medizinische Klinik und Poliklinik