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Dokumenttyp:
journal article 
Autor(en):
Wermter, AK; Scherag, A; Meyre, D; Reichwald, K; Durand, E; Nguyen, TT; Koberwitz, K; Lichtner, P; Meitinger, T; Schäfer, H; Hinney, A; Froguel, P; Hebebrand, J; Brönner, G 
Titel:
Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans. 
Abstract:
DLK1 is part of the Notch signalling pathway that controls various developmental processes. A functional role for DLK1 in adipogenesis is suggested by several animal models. Interestingly, the DLK1 gene is imprinted in eutherian mammals. To study whether variations in DLK1 affect body weight in humans, we analysed 32 polymorphisms in a 109 kb genomic region encompassing DLK1 on human chromosome 14. In a study sample of 1025 French and German trio families comprised of both parents and extremely...    »
 
Zeitschriftentitel:
Eur J Hum Genet 
Jahr:
2008 
Band / Volume:
16 
Heft / Issue:
Seitenangaben Beitrag:
1126-34 
Sprache:
eng 
Print-ISSN:
1018-4813 
TUM Einrichtung:
r Humangenetik