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Document type:
journal article 
Author(s):
Sinner, MF; Pfeufer, A; Akyol, M; Beckmann, BM; Hinterseer, M; Wacker, A; Perz, S; Sauter, W; Illig, T; Näbauer, M; Schmitt, C; Wichmann, HE; Schömig, A; Steinbeck, G; Meitinger, T; Kääb, S 
Title:
The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG). 
Abstract:
AIMS: Atrial fibrillation (AF) is the most frequent arrhythmia in humans. Rare familial forms exist. Recent evidence indicates a genetic susceptibility to common forms of AF. The alpha-subunit of the myocardial I(Kr)-channel, encoded by the KCNH2 gene, is crucial to ventricular and atrial repolarization. Patients with mutations in KCNH2 present with higher incidence of AF. Common variants in KCNH2 have been shown to modify ventricular repolarization. We intended to investigate, whether such vari...    »
 
Journal title abbreviation:
Eur Heart J 
Year:
2008 
Journal volume:
29 
Journal issue:
Pages contribution:
907-14 
Language:
eng 
Print-ISSN:
0195-668X 
TUM Institution:
r Humangenetik; I. Medizinische Klinik und Poliklinik