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Document type:
journal article 
Author(s):
Hinterseer, M; Thomsen, MB; Beckmann, BM; Pfeufer, A; Schimpf, R; Wichmann, HE; Steinbeck, G; Vos, MA; Kaab, S 
Title:
Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study. 
Abstract:
AIMS: Torsades de pointes arrhythmias (TdP) occur by definition in the setting of prolonged QT intervals. Animal models of drug induced Long-QT syndrome (dLQTS) have shown higher predictive value for proarrhythmia with beat-to-beat variability of repolarization duration (BVR) when compared with QT intervals. Here, we evaluate variability of QT intervals in patients with a history of drug-induced long QT syndrome (dLQTS) and TdP in absence of a mutation in any of the major LQTS genes. METHODS AND...    »
 
Journal title abbreviation:
Eur Heart J 
Year:
2008 
Journal volume:
29 
Journal issue:
Pages contribution:
185-90 
Language:
eng 
Print-ISSN:
0195-668X 
TUM Institution:
r Humangenetik