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Dokumenttyp:
journal article 
Autor(en):
Hoffmann, TK; Sonkoly, E; Hauser, U; van Lierop, A; Whiteside, TL; Klussmann, JP; Hafner, D; Schuler, P; Friebe-Hoffmann, U; Scheckenbach, K; Erjala, K; Grénman, R; Schipper, J; Bier, H; Balz, V 
Titel:
Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma. 
Abstract:
Chemotherapy and/or radiotherapy are established measures in treatment protocols of head and neck squamous cell carcinoma (HNSCC). However, we still lack reliable predictive markers for the response to radio- and chemotherapy. The p53 pathway is involved in stress response and thus might influence chemo-/radiosensitivity. Using 29 HNSCC cell lines previously characterized for p53 mutations, we simultaneously analyzed several key players in the p53 pathway by RT-PCR, transcript sequencing and imm...    »
 
Zeitschriftentitel:
Oral Oncol 
Jahr:
2008 
Band / Volume:
44 
Heft / Issue:
12 
Seitenangaben Beitrag:
1100-9 
Sprache:
eng 
Print-ISSN:
1368-8375 
TUM Einrichtung:
Hals-, Nasen-, Ohrenklinik und Poliklinik