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Document type:
journal article 
Author(s):
Ito, D; Visus, C; Hoffmann, TK; Balz, V; Bier, H; Appella, E; Whiteside, TL; Ferris, RL; DeLeo, AB 
Title:
Immunological characterization of missense mutations occurring within cytotoxic T cell-defined p53 epitopes in HLA-A*0201+ squamous cell carcinomas of the head and neck. 
Abstract:
Previous analyses of p53 in 40 HLA-A*0201(HLA-A2)(+) squamous cell carcinomas of the head and neck (SCCHN) indicated that 6/13 p53 missense mutations that were detected, S149C, T150R, V157F, Y220C, Y220H and E271K, occurred within HLA-A2-restricted cytotoxic T lymphocyte (CTL)-defined p53 epitopes. Of the 6, the p53 S149C, Y220C and Y220H peptides were immunogenic. Anti-p53 mutant S149C and Y220H effector cells cross-reacted against the parental wild type sequence (wt) p53 peptides, whereas anti...    »
 
Journal title abbreviation:
Int J Cancer 
Year:
2007 
Journal volume:
120 
Journal issue:
12 
Pages contribution:
2618-24 
Language:
eng 
Print-ISSN:
0020-7136 
TUM Institution:
Hals-, Nasen-, Ohrenklinik und Poliklinik